Contents of matrix metalloproteinase type 2 (MMP-2) and complexes MMP-9/TIMP-1, MMP-2/TIMP-2, and total cholesterol in practically healthy people and patients with hypertension

Arterial hypertension (AH) is the most common age-associated disease among working population. Polyetiology of AH requires a more thorough definition and study its predictors aiming for understanding role external influences, as well detection genetic polymorphisms at early stages, in order to limit their implementation. The scientific reviews discuss important abnormal vascular remodeling pathogenesis hypertension. main factor such alterations rearrangement extracellular matrix due metalloproteinases (MMP), zinc-dependent enzymes with wide substrate specificity. In addition, than 70% cases, combined lipid metabolism disorders, including an increase cholesterol levels. These mechanisms should be taken into account when assessing risk factors development cardiovascular accidents. MMP-2 complexes MMP- 9/ TIMP- 1, MMP-2/TIMP-2 restructuring insufficiently described review articles. article presents our results studying system proteolytic level total 110 practically healthy people 90 persons aged 18 74 years old. levels MMP-2, MMP-9/ blood serum were studied by sandwich variant ELISA technique. Statistical processing obtained data was carried out using analytical software IBM SPSS Statistics, v. 22.0.1. It found that groups women, regardless presence, or absence pathology, higher if compared male subjects. values low both general group people, gender, men Proteolytic activity shows broader women we have registered lower MMP tissue inhibitors. An imbalance proteolysis/antiproteolysis observed hypertensive pronounced effects upon migration, proliferation apoptosis smooth muscle cells, endothelial inflammatory thus determining formation intima arterial remodeling, predominance affects rigidity wall.